Selected Papers

  • Universal Single Copy Knock-In System in Caenorhabditis elegans: One Plasmid to Target All Chromosomes.

    Erica Dinneen and Carlos G. Silva-García.

    bioRxiv (2024) — PDF

  • The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.

    Carlos G. Silva-García, Laura I. Láscarez-Lagunas, Katharina Papsdorf, Caroline Heintz, Aditi Prabhakar, Christopher S. Morrow, Lourdes Pajuelo Torres, Arpit Sharma, Jihe Liu, Monica P. Colaiácovo, Anne Brunet and William B. Mair.

    Nature Aging (2023) — PDF

  • Devo-Aging: Intersections Between Development and Aging.

    Carlos G. Silva-García.

    GeroScience (2023) — PDF

  • Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.

    Katharina Papsdorf, Jason W. Miklas, Amir Hosseini, Matias Cabruja, Christopher S. Morrow, Marzia Savini, Yong Yu, Carlos G. Silva-García, Nicole R. Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J. Dixon, Michael P. Snyder, Meng C. Wang, William B. Mair, and Anne Brunet.

    Nature Cell Biology (2023) — PDF

  • GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.

    Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W. Skinner, Kerstin A. Baran, Laura I. Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G. Silva-García, Takamune T. Saito, Sara Beese-Sims, Brianna N. Diaz-Pacheco, Elizaveta Berson, Ana B. Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W. Jordan, and Monica P. Colaiácovo.

    Plos Genetics (2023) — PDF

  • Confirming the pro-longevity effects of H3K4me3-deficient set-2 mutants in extending lifespan in C. elegans.

    Carlos G. Silva-García and William B. Mair.

    bioRxiv (2022) — PDF

  • Single-copy knock-in loci for defined gene expression in Caenorhabditis elegans. —aka SKI LODGE

    Carlos G. Silva-García, Anne Lanjuin, Caroline Heintz, Sneha Dutta, Nicole M. Clark, and William B. Mair.

    G3 Genes|Genomes|Genetics (2019) — PDF

  • Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans.

    Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G. Silva-García, Heather J Weir, Chia-Lin Lee, Caroline C Escoubas, Emina Tabakovic, and William B Mair.

    eLIFE (2019) — PDF

  • Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.

    Shuo Han, Elizabeth A. Schroeder*, Carlos G. Silva-García*, Katja Hebestreit, William B. Mair, and Anne Brunet.

    Nature (2017) *Equal contribution — PDF

  • Deregulation of CRTCs in aging and age-related disease risk.

    Caroline C. Escoubas*, Carlos G. Silva-García*, and William B. Mair.

    Trends in Genetics (2017) *Equal contribution — PDF

  • Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

    Caroline Heintz, Thomas K. Doktor, Anne Lanjuin1, Caroline C. Escoubas, Yue Zhang, Heather J. Weir, Sneha Dutta, Carlos G. Silva-García, Gitte H. Bruun, Ianessa Morantte, Gerta Hoxhaj, Brendan D. Manning, Brage S. Andresen, and William B. Mair.

    Nature (2017) — PDF

  • The stress granule RNA-binding protein TIAR-1 protects female germ cells from heat shock in Caenorhabditis elegans.

    Gabriela Huelgas-Morales, Carlos G. Silva-García, Laura S. Salinas, David Greenstein, and Rosa E. Navarro.

    G3 Genes|Genomes|Genetics (2016) — PDF

  • LIN-35/Rb Causes Starvation-Induced Germ Cell Apoptosis via CED-9/Bcl2 Downregulation in Caenorhabditis elegans.

    Laura I. Láscarez-Lagunas, Carlos G. Silva-García, Tzvetanka D. Dinkova, and Rosa E. Navarro.

    Molecular and Cell Biology (2014) — PDF

  • The C. elegans TIAR-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis.

    Carlos G. Silva-García and Rosa E. Navarro.

    Genesis (2013) — PDF