Selected Papers

  • Carlos G. Silva-García, Laura I. Láscarez-Lagunas, Katharina Papsdorf, Caroline Heintz, Aditi Prabhakar, Christopher S. Morrow, Lourdes Pajuelo Torres, Arpit Sharma, Jihe Liu, Monica P. Colaiácovo, Anne Brunet and William B. Mair (2023). The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans. Nature Aging, PDF

  • Carlos G. Silva-García (2023). Devo-Aging: Intersections Between Development and Aging. GeroScience, PDF

  • Katharina Papsdorf, Jason W. Miklas, Amir Hosseini, Matias Cabruja, Christopher S. Morrow, Marzia Savini, Yong Yu, Carlos G. Silva-García, Nicole R. Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J. Dixon, Michael P. Snyder, Meng C. Wang, William B. Mair, and Anne Brunet (2023). Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids. Nature Cell Biology, PDF

  • Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W. Skinner, Kerstin A. Baran, Laura I. Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G. Silva-García, Takamune T. Saito, Sara Beese-Sims, Brianna N. Diaz-Pacheco, Elizaveta Berson, Ana B. Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W. Jordan, and Monica P. Colaiácovo (2023). GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. Plos Genetics, PDF

  • Carlos G. Silva-García and William B. Mair (2022). Confirming the pro-longevity effects of H3K4me3-deficient set-2 mutants in extending lifespan in C. elegans. bioRxiv, PDF

  • Carlos G. Silva-García, Anne Lanjuin, Caroline Heintz, Sneha Dutta, Nicole M. Clark, and William B. Mair (2019). Single-copy knock-in loci for defined gene expression in Caenorhabditis elegans (SKI LODGE). G3 Genes|Genomes|Genetics, PDF

  • Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G. Silva-García, Heather J Weir, Chia-Lin Lee, Caroline C Escoubas, Emina Tabakovic, and William B Mair (2019). Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans. eLIFE, PDF

  • Shuo Han, Elizabeth A. Schroeder*, Carlos G. Silva-García*, Katja Hebestreit, William B. Mair, and Anne Brunet (2017). Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature, *Equal contribution, PDF

  • Caroline C. Escoubas*, Carlos G. Silva-García*, and William B. Mair (2017). Deregulation of CRTCs in aging and age-related disease risk. Trends in Genetics, *Equal contribution, PDF

  • Caroline Heintz, Thomas K. Doktor, Anne Lanjuin1, Caroline C. Escoubas, Yue Zhang, Heather J. Weir, Sneha Dutta, Carlos G. Silva-García, Gitte H. Bruun, Ianessa Morantte, Gerta Hoxhaj, Brendan D. Manning, Brage S. Andresen, and William B. Mair (2017). Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature, PDF

  • Gabriela Huelgas-Morales, Carlos G. Silva-García, Laura S. Salinas, David Greenstein, and Rosa E. Navarro (2016). The stress granule RNA-binding protein TIAR-1 protects female germ cells from heat shock in Caenorhabditis elegans. G3 Genes|Genomes|Genetics, PDF

  • Laura I. Láscarez-Lagunas, Carlos G. Silva-García, Tzvetanka D. Dinkova, and Rosa E. Navarro (2014). LIN-35/Rb Causes Starvation-Induced Germ Cell Apoptosis via CED-9/Bcl2 Downregulation in Caenorhabditis elegans. Molecular and Cell Biology, PDF

  • Carlos G. Silva-García and Rosa E. Navarro (2013). The C. elegans TIAR-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis, PDF